Cytoscape Web
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Gastrointestinal stromal tumor
1 OMIM reference -
5 associated genes
112 connected diseases
18 signs/symptoms
Disease Type of connection
Hereditary pheochromocytoma-paraganglioma
Cowden syndrome
Carney-Stratakis syndrome
Isolated succinate-CoQ reductase deficiency
Precursor B-cell acute lymphoblastic leukemia
Idiopathic hypereosinophilic syndrome
Acute myeloblastic leukemia with maturation
Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)
Acute myeloid leukemia with t(8;21)(q22;q22) translocation
Aleukemic mast cell leukemia
Bullous diffuse cutaneous mastocytosis
Classic mast cell leukemia
Cutaneous mastocytoma
Isolated bone marrow mastocytosis
Lymphoadenopathic mastocytosis with eosinophilia
Myeloid neoplasm associated with PDGFRA rearrangement
Nodular urticaria pigmentosa
Piebaldism
Plaque-form urticaria pigmentosa
Pseudoxanthomatous diffuse cutaneous mastocytosis
Smouldering systemic mastocytosis
Systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease
Telangiectasia macularis eruptiva perstans
Typical urticaria pigmentosa
Familial isolated dilated cardiomyopathy
Leigh syndrome with leukodystrophy
Juvenile myelomonocytic leukemia
Autosomal agammaglobulinemia
Distal 22q11.2 microdeletion syndrome
Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis
Bilateral striopallidodentate calcinosis
SHORT syndrome
Chronic myeloid leukemia
Precursor T-cell acute lymphoblastic leukemia
LEOPARD syndrome
Metachondromatosis
Noonan syndrome
Noonan syndrome-like disorder with juvenile myelomonocytic leukemia
Chronic mucocutaneous candidiasis
Mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency
Susceptibility to viral and mycobacterial infections
Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
Acute promyelocytic leukemia
Laron syndrome with immunodeficiency
Congenital pulmonary alveolar proteinosis
Chronic myelomonocytic leukemia
Dermatofibrosarcoma protuberans
Familial multiple meningioma
Familial progressive hyper- and hypopigmentation
Familial progressive hyperpigmentation
Infantile myofibromatosis
Myeloid neoplasm associated with PDGFRB rearrangement
Testicular non seminomatous germ cell tumor
Testicular seminomatous germ cell tumor
Unclassified chronic myeloproliferative disease
Dominant hypophosphatemia with nephrolithiasis or osteoporosis
Growth retardation-mild developmental delay-chronic hepatitis syndrome
Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus
Berardinelli-Seip congenital lipodystrophy
Diffuse cutaneous systemic sclerosis
Heritable pulmonary arterial hypertension
Limited cutaneous systemic sclerosis
Severe combined immunodeficiency due to LCK deficiency
Budd-Chiari syndrome
Essential thrombocythemia
Familial thrombocytosis
Myelofibrosis with myeloid metaplasia
Polycythemia vera
Capillary malformation - arteriovenous malformation
Parkes Weber syndrome
Congenital communicating hydrocephalus
Autosomal dominant limb-girdle muscular dystrophy type 1C
Rippling muscle disease
Romano-Ward syndrome
Autosomal dominant macrothrombocytopenia
Fetal and neonatal alloimmune thrombocytopenia
Glanzmann thrombasthenia
Common variable immunodeficiency
Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation
Familial idiopathic steroid-resistant nephrotic syndrome with minimal changes
Inflammatory myofibroblastic tumor
Translocation renal cell carcinoma
Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation
Cherubism
Combined immunodeficiency due to ZAP70 deficiency
MODY syndrome
PLCG2-associated antibody deficiency and immune dysregulation
X-linked lymphoproliferative disease
Primary familial polycythemia
Omenn syndrome
T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency
Bannayan-Riley-Ruvalcaba syndrome
Dedifferentiated liposarcoma
Familial thoracic aortic aneurysm and aortic dissection
Hereditary breast and ovarian cancer syndrome
Hereditary nonpolyposis colon cancer
Juvenile polyposis of infancy
Lhermitte-Duclos disease
Loeys-Dietz syndrome type 1
Macrocephaly-autism syndrome
Marfan syndrome type 2
Proteus syndrome
Proteus-like syndrome
Segmental outgrowth - lipomatosis - arteriovenous malformation - epidermal nevus
Squamous cell carcinoma of head and neck
Well-differentiated liposarcoma
Carcinoid tumor and carcinoid syndrome
Legius syndrome
Autosomal dominant hyper-IgE syndrome
Short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia
T-B+ severe combined immunodeficiency due to JAK3 deficiency
X-linked agammaglobulinemia
Synonym(s):
- GIST
Classification (Orphanet):
- Rare gastroenterologic disease
- Rare genetic disease
- Rare oncologic disease
Classification (ICD10):
- Neoplasms -
Epidemiological data:
Class of prevalence: 1-5 / 10 000
Average age onset: adulthood
Average age of death: -
Type of inheritance: sporadic
External references:
1 OMIM reference -
1 MeSH reference: D046152
Very frequent
- Estomach / gastric neoplasm / tumor / carcinoma / cancer
- Sarcoma

Frequent
- Asthenia / fatigue / weakness
- Constipation
- Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia
- Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia
- Intestinal obstruction / ileus
- Intestinal perforation
- Nausea / vomiting / regurgitation / merycism / hyperemesis

Occasional
- Anaemia
- Colon neoplasm / tumor / carcinoma / cancer
- Cutaneous rash
- Digestive neoplasm / tumor / carcinoma / cancer
- Esophageal neoplasm / tumor / carcinoma / cancer
- Hepatitis / icterus / cholestasis
- Irregular / in bands / reticular skin hyperpigmentation
- Rectum / rectal neoplasm / tumor / carcinoma / cancer
- Small bowel neoplasm / tumor / carcinoma / cancer